A press conference will be held in September to report on the research results of Shunga grape seed components conducted from December 2020 to June 2023 by the Nabeshima Laboratory of Kyoto University School of Medicine and the Uto Laboratory of Tokushima University. It was held on the 22nd.

　Professor Alipov Gavit, a doctor who conducted human clinical trials, also took to the podium on the day to discuss the results of research into a Japanese-originated ingredient that is groundbreaking for cancer patients, especially those suffering from breast cancer around the world. The presentation was titled, “Research presentation on ingredients that enhance the effectiveness of anticancer drugs and significantly reduce side effects – An approach to eradicating breast cancer,” and future challenges were also introduced.

　At this press conference, research results were announced on a component of instant grape seed that dramatically increases the cancer suppressing effect compared to the use of anticancer drugs alone. At the beginning, specially appointed professor Yoichi Nabeshima of Kyoto University School of Medicine spoke about the purpose of the event as follows:

 “As you know, cancer is the number one cause of death. Humankind has made great efforts to combat cancer, but cancer remains the number one cause of death. In recent years, there have been many spectacular research results. However, many people are dying from cancer.I think the time has come for us to use our wisdom and try something new.We learned about the very interesting functions of the ingredients of the Shunbud Grape Seed. I felt that it had the potential to create a new stage in cancer research, and I wanted to spread the word not only through conference presentations but also to the general public.”

　Professor Yoshihiro Uto of Tokushima University, who has been researching the components of instant bud grape seeds for many years, immediately explains the components of instant bud grape seeds.

 “There has been a great deal of research into grape seeds (which are known to be rich in nutrients), but instant budding grape seed ingredients are ingredients that instantly germinate grape seeds under certain conditions to promote germination. It is a product extracted from various factors produced in grape seeds.It has been confirmed that it contains various new components that are not well-known components contained in normal grape seeds.

　The components of bud grape seeds have an extremely wide range of functionality, including antioxidant activity, anti-inflammatory activity, and anti-aging activity, and Professor Uto and his colleagues have been conducting research with a particular focus on anti-tumor activity. At the case level at university hospitals, the combination of anticancer drugs has shown that cancer has shrunk in a large number of people. It has already been reported that the side effects of anticancer drugs are greatly suppressed.

 “We are conducting joint research on the anti-tumor activity of the components of instant grape seeds, including Tokushima University, Kyoto University, and Kazakhstan University of Medical Sciences, to elucidate their functionality. We are aiming to implement it in society so that everyone can use it.” (Mr. Uto)

 “When we add instant grape seed ingredients to cancer cells in mice, 50% of the cancer cells die at very low concentrations.Moreover, it is known to be very fast-acting and highly resistant. Similar effects were observed in triple-negative breast cancer cells, as well as in normal breast, liver, prostate, and uterine cancer cells.Because it is effective at low concentrations, it is not toxic in healthy human cells. We found that it was selectively effective only against cancer cells.” (Mr. Uto)

　Research results on the effects of combined use with anticancer drugs were also introduced, stating that the side effects of anticancer drugs are greatly suppressed.

 “This research was conducted because weakening the effect of anticancer drugs could affect anticancer drug treatment, but this study used breast cancer cells. When anticancer drugs were introduced into tumor cells at the same time and the concentration was adjusted, it was found that there was a synergistic and additive effect.Depending on the concentration, There are some antagonistic effects, but if you choose the concentration, you can get a synergistic effect.” (Mr. Uto)

　In hormone receptor-positive breast cancer, which is the most common type of breast cancer, the anticancer activity was approximately 10 times more effective. So far, the research results seem to have been based on cell models, but even when administered intravenously using animal models, the ingredients reached the cancer and similar effects were obtained.

“In experiments on the combined effect of suppressing tumor growth using animal models, the combination of anticancer drugs and instant grape seed ingredients reduced the size of tumors at once,” said Uto. It is said that the components of the instant grape seeds are thought to have an inhibitory effect on all types of cancer, including breast cancer.

Alipov Gavit, former professor at Kazakhstan Medical University and Almaty Cancer Center, has conducted human clinical trials and found that in 92% of people, the side effects of anticancer drugs are kept to a level that does not interfere with daily life. introduction. He said, “Its effectiveness as a countermeasure against side effects of anticancer drugs has exceeded expectations.”

Chiaki Abe, a special assistant professor at the Kyoto University School of Medicine and Graduate School of Medicine, told us about the currently known mechanisms of anti-tumor and cancer-suppressing effects. It is speculated that the components of budding grape seeds promote strong cancer-suppressing effects through an extremely rare mechanism in which two pathways, apoptosis and necrosis, work together.

　A research team from Kyoto University and Tokushima University also presented these findings at the 82nd Annual Meeting of the Japanese Cancer Society, held from September 21 to 23. Issues that need to be resolved in the future include further elucidation of the antitumor activity mechanism of the components of instant grape seeds, elucidation of the mechanism that reduces the side effects of anticancer drugs, and the implementation of human clinical trials and research for various cancers. was mentioned.

 “This time, we conducted experiments on all major human carcinomas, but there are still many cancers out there.Also, regarding the effectiveness of combinations with anticancer drugs, this time we evaluated only the anticancer drug doxorubicin. Although we are looking specifically at breast cancer, we will also examine whether other anticancer drugs can have the same enhancing effect and whether they do not affect the main action of the anticancer drug.Animal models We are also planning the next clinical trial with Dr. Alipov and Dr. Nabeshima, with a view to evaluation through human clinical trials and verification through human clinical trials.” (Mr. Uto)